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Thesis

Asymmetric synthesis of the Martinella alkaloids

Abstract:

This thesis is concerned with the application of the conjugate addition of enantiopure lithium amides in the asymmetric syntheses of (−)-martinellic acid.

Chapter 1 introduces the importance of the quinoline motif in a wide variety of natural products and pharmaceuticals. The natural products (–)-martinellic acid and (+)-martinelline are introduced and previous methods for their synthesis are described.

Chapter 2 introduces the conjugate addition reaction of lithium N-benzyl-...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Stephen G Davies Group
Oxford college:
New College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:e8bcf4df-c046-4daf-9f87-12190e3992c3
Local pid:
ora:7873
Deposit date:
2014-02-03

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