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Thesis

Identification of novel strategies to radiosensitise tumour cells

Abstract:

In this study we found that tumour cells can be radiosensitised by targeting the DNA damage response kinases, ATM and ATR. Furthermore, we highlight that Wee1 inhibitors, which are already under the clinical trials need to be further investigated in combination with radiation in the context of tumour hypoxia. In addition, we observed that induction of autophagy using STF-62247 can lead to radiosensitisation of VHL deficient RCC cells. Our studies with the rapamycin analogue temsirolimus, a...

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Institution:
University of Oxford
Oxford college:
St Edmund Hall
Department:
Medical Sciences Division

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:e826a95f-7a16-401d-827c-5afc8003b924
Local pid:
ora:10647
Language:
English
Keywords:
Subjects:

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