Protein post-translational modification mimicry for cargo sortingto extracellular vesicles

Thesis

Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles released by cells that facilitate the intercellular transfer of proteins and nucleic acids. This intrinsic delivery property of EVs, together with their low immunogenicity and potential for repeat administration, makes them promising delivery vehicles for novel therapeutics.

The loading of cargo molecules into EVs constitutes one of the main challenges limiting clinical translation of EV-based therapies. Post-...

Expand abstract

Authors: Martin, C

• DOI: 10.5287/ora-14yvonx7m
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: EV; Exosomes; Therapeutic delivery; Extracellular vesicles
• Subjects: Molecular biotechnology