Thesis

In vitro and in vivo investigation into the role of lysine specific demethylases in the molecular circadian oscillator

Abstract:: Lysine Specific Demethylases (LSD1 and LSD2 also known as KDM1A and KDM1B) are histone modifiers known to specifically demethylate dimethyl and monomethyl H3K4. They play roles in development and cancer mechanisms through regulation of the cell cycle and progenitor differentiation pathways but have not yet been characterised in the circadian system.

LSD1 and LSD2 were shown to play a role in circadian oscillation in vitro in unpublished preliminary work. Knockdown of either...
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APA Style

Shepherd, H. (2015). In vitro and in vivo investigation into the role of lysine specific demethylases in the molecular circadian oscillator [PhD thesis]. University of Oxford.

MLA Style

Shepherd, H. In Vitro and in Vivo Investigation into the Role of Lysine Specific Demethylases in the Molecular Circadian Oscillator. 2015. University of Oxford, PhD thesis.

Chicago Style

Shepherd, H. 2015. “In Vitro and in Vivo Investigation into the Role of Lysine Specific Demethylases in the Molecular Circadian Oscillator.” PhD thesis, University of Oxford.
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Authors

+ Shepherd, H More by this author

Institution:: University of Oxford
Oxford college:: St John's College
Role:: Author

Contributors

Department:: MRC Harwell
Role:: Supervisor

Role:: Supervisor

+ Medical Research Council More from this funder

DOI:: 10.5287/ora-9e5poxbp7
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: University of Oxford

Language:: English
Keywords:: Harwell

Circadian

Mouse

ENU

Phenotype

Ophthalmology
Subjects:: Circadian rhythms

Phenotype

Neurosciences

England--Harwell
UUID:: uuid:e73126aa-14f4-45e0-a040-10b34983dbf9
Deposit date:: 2016-03-01
ARK identifier:: ark:/29072/ora_e73126aa14f445e0a04010b34983dbf9

Terms of use

Copyright holder:: Shepherd, H
Copyright date:: 2015

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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