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In vitro and in vivo investigation into the role of lysine specific demethylases in the molecular circadian oscillator

Abstract:

Lysine Specific Demethylases (LSD1 and LSD2 also known as KDM1A and KDM1B) are histone modifiers known to specifically demethylate dimethyl and monomethyl H3K4. They play roles in development and cancer mechanisms through regulation of the cell cycle and progenitor differentiation pathways but have not yet been characterised in the circadian system.

LSD1 and LSD2 were shown to play a role in circadian oscillation in vitro in unpublished preliminary work. Knockdown of either...

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Department:
St johns College
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Department:
MRC Harwell
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Supervisor
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Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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