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Thesis

Characterising the small heat shock proteins: structure and regulation

Alternative title:
Structural and functional studies of HSP27 (HSPB1) and disease-related mutations. including investigating the role of oxidation and phosphorylation in HSP27 regulation
Abstract:

The small heat shock protein HSP27 is expressed throughout the body and involved in a variety of cellular processes. Its multiple roles may all be mediated by its ability to chaperone partially folded protein substrates, and its malfunction is implicated in a range of diseases such as motor neuropathy and neurodegeneration. Here I describe structural, dynamical and functional investigations into this protein, particularly regarding its regulation by oxidation and phosphorylation. The found...

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Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
More from this funder
Name:
Engineering and Physical Sciences Research Council
Funding agency for:
Gastall, H
Grant:
Systems Biology Doctoral Training Centre
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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