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Role of the glucose-6-phosphate translocase on bacterial handling in human macrophages

Abstract:

Disruption of the homeostatic balance in the intestine of genetically susceptible individuals can lead to inflammatory bowel disease (IBD), such as Crohn's disease (CD) or ulcerative colitis (UC). Defects in glucose-6-phosphate metabolism due to defects in glucose-6-phosphatase or glucose-6-phosphate translocase cause a rare Mendelian form of congenital neutropenia and CD like intestinal inflammation. The aim of this project is to investigate the mechanisms by which defective metabolism i...

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Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
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