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Thesis

T cell-mediated immune regulation in spondyloarthritis

Abstract:

CD4+ T cells are essential components of the immune system. Dysregulated or excessive T cell responses can cause, in susceptible individuals, a group of immune-mediated conditions termed Spondyloarthritis (SpA), characterized by chronic inflammation and structural damage of various musculoskeletal structures. While well-documented genetic and immunological alterations in SpA explain the overactivation of effector T cells, the intrinsic regulatory functions exerted by a specialized T cell s...

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Division:
MSD
Department:
NDORMS
Role:
Author

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Role:
Supervisor
ORCID:
0000-0003-4307-9161
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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