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Thesis

Investigating the contribution of alternative polyadenylation to the regulation of gene expression

Abstract:

Around 70% of human genes have been found to contain multiple cleavage and polyadenylation (pA) sites. The alternative usage of these different pA sites is referred to as alternative cleavage and polyadenylation (APA). A wide range of studies have described switches in APA profiles when comparing different cell types and different cell states, notably general shifts to shorter APA isoforms upon the onset of cancer. These shifts have been described at both the individual gene and...

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Department:
Oxford University

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Supervisor
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Grant:
1243663
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Type of award:
DPhil
Awarding institution:
University of Oxford

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