Epigenetic mechanisms in silico: understanding demethylation and rational design of bromodomain inhibitors

Thesis

Histone octamer proteins are crucial for DNA packaging and storage in the confined space of the cell nucleus. Epigenetic post-translational modifications to specific histone monomers facilitate changes in chromatin flexibility that are necessary for access by transcription machinery, and therefore have control over gene expression. Targeting enzymes that regulate these powerful modifications has been established as a promising strategy in the treatments of some diseases, such as cance...

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Authors: Coelho, W

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford