A current perspective on wound healing and tumour-induced angiogenesis

Journal article

Angiogenesis, or capillary growth from pre-existing vasculature, is an essential component of several physiological processes, both vital and pathological. These include dermal wound healing and tumour growth that together pose some of the most significant challenges to healthcare systems worldwide. Over the last few decades, mathematical modelling has proven to be a valuable tool for unravelling the complex network of interactions that underlie such processes. Moreover, theoretical frameworks that describe some of the mechanical and chemical aspects of angiogenesis inherent in wound healing and tumour growth have revealed intriguing similarities between the two processes. In this review, we highlight some of the significant contributions made by mathematical models of tumour-induced and wound healing angiogenesis and illustrate how advances in each field have been made using insights from the other. We also detail some open problems that could be addressed through a combination of theoretical and experimental approaches.

Authors: Flegg, JA; Menon, SN; Byrne, HM; McElwain, DLS

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: Bulletin of Mathematical Biology
• Volume: 82
• Article number: 23
• Publication date: 2020-01-22
• Acceptance date: 2020-01-02
• DOI: 10.1007/s11538-020-00696-0
• EISSN: 1522-9602
• ISSN: 0092-8240
• Language: English
• Keywords: mathematical modelling; wound healing; angiogenesis; tumours; FFR