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Thesis

Selective modification and detection of the DNA bases

Abstract:

α-Hemolysin (αHL) is a biological nanopore, which is currently under investigation for implementation into a new method for DNA sequencing. It has been established that αHL is capable of discriminating the canonical bases (adenine, cytosine, guanine and thymine) when they are immobilised within a pore by means of a biotin•streptavidin complex. Work in this thesis develops this procedure for the discrimination of these standard nucleobases from the the epigenetic modifications of cytosine –...

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Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory

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Role:
Supervisor
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:e30564de-0a84-4665-b7af-66a8ea589801
Local pid:
ora:6241
Language:
English
Keywords:
Subjects:

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