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Characterization of the interactions between the H3K4 demethylase JARID1A and the SCL-nucleated oncogenic DNA binding complex

Abstract:

Transcriptional regulation is of key importance to cellular processes such as development and differentiation, and it is dependent on the accessibility of DNA in the chromatin. Methylation and demethylation of histones alter properties of nucleosomes, thereby changing the accessibility of DNA. For many years, histone tail methylation was considered to be irreversible but in the last decade two families of histone demethylases were discovered, lysine specific demethylase 1 (LSD1) and Jumonj...

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Department:
University of Oxford
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Copyright Holder, Author

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Grant:
B5RRNB0
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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