Thesis
A randomised control trial of 5-aminolevulinic acid in combination with sodium ferrous citrate to enhance cardioprotection in adults undergoing cardiac surgery (TALEN)
- Abstract:
-
Haem oxygenase-1 (HO-1) is an evolutionarily highly conserved, ubiquitously expressed protein with critical antioxidant and pro-survival effects, primarily responsible for catalysing haem breakdown into equimolar quantities of carbon monoxide, biliverdin, and ferrous iron – each bioactive signalling molecules. Through its enzymatic role to catabolise haem, as well as through multiple non-enzymatic functions including favourable effects on immune cell regulation, immunometabolism and iron h...
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Authors
Contributors
+ Ashrafian, H
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Supervisor
+ Rowland, M
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Sayeed, R
Role:
Supervisor
+ Yavari, A
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Supervisor
ORCID:
0000-0002-0815-5088
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
-
2024940
- Local pid:
-
pubs:2024940
- Deposit date:
-
2024-08-31
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