Thesis
A randomised control trial of 5-aminolevulinic acid in combination with sodium ferrous citrate to enhance cardioprotection in adults undergoing cardiac surgery (TALEN)
- Abstract:
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Haem oxygenase-1 (HO-1) is an evolutionarily highly conserved, ubiquitously expressed protein with critical antioxidant and pro-survival effects, primarily responsible for catalysing haem breakdown into equimolar quantities of carbon monoxide, biliverdin, and ferrous iron – each bioactive signalling molecules. Through its enzymatic role to catabolise haem, as well as through multiple non-enzymatic functions including favourable effects on immune cell regulation, immunometabolism and iron h...
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- Files:
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(Preview, Dissemination version, pdf, 27.6MB, Terms of use)
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Authors
Contributors
+ Ashrafian, H
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- RDM
- Sub department:
- RDM Cardiovascular Medicine
- Role:
- Supervisor
+ Rowland, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
+ Sayeed, R
- Role:
- Supervisor
+ Yavari, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- RDM
- Role:
- Supervisor
- ORCID:
- 0000-0002-0815-5088
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
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2024940
- Local pid:
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pubs:2024940
- Deposit date:
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2024-08-31
- ARK identifier:
Terms of use
- Copyright holder:
- Kingwill, AC
- Copyright date:
- 2024
- Licence:
- CC Attribution (CC BY)
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