Thesis
P450–Mediated azepane natural product synthesis
- Abstract:
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Chapter 1 introduces methods and applications for C–H activation, cytochrome P450 enzymes and their uses in synthesis, and the relevant families of compounds in which the present work takes place.
Chapter 2 describes the strategy and the attempts of building the natural product balanol and analogues via C–H amination from enzymatically made substrate, along with new bicyclic lactones synthesised via C–H activation.
Chapter 3 presents progress in the synthesis of the carbon skeleton of the natural product cephalotaxine via an intramolecular Schmidt reaction, along with a significantly improved literature method for assembling the cephalotaxine core.
Chapter 4 explores the P450-catalysed oxidations of the previously made cephalotaxine core structure, to access new analogues of this natural product and to draw a P450-reactivity profile of this molecule.
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- Files:
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(Preview, Dissemination version, pdf, 7.3MB, Terms of use)
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Authors
Contributors
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Sub department:
- Organic Chemistry
- Research group:
- Robertson group
- Oxford college:
- Brasenose College
- Role:
- Supervisor
- ORCID:
- 0000-0002-6809-8265
- DOI:
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2023-12-16
- ARK identifier:
Terms of use
- Copyright holder:
- Virgile Annibale Auguste Rouffeteau
- Copyright date:
- 2023
- Licence:
- CC Attribution (CC BY)
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