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An investigation into the molecular mechanism of the fibrillin1 - LTBP1 interaction

Abstract:

Many studies have demonstrated a connection between the fibrillin matrix and TGFβ signalling, but at present the mechanistic basis for this link is unclear. An interaction between the C-terminus of Latent TGFβ Binding Protein 1 (LTBP1) and the N-terminus of fibrillin1 has previously been identified, and may have the potential to directly link the fibrillin matrix to TGFβ signalling.

To investigate the structural basis for this interaction, several multi-domain fragments of fibrillin...

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Institution:
University of Oxford
Research group:
Handford Lab
Oxford college:
Somerville College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:e154e0a2-c0cb-42bd-8b90-7a13460700c0
Local pid:
ora:9371

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