- Abstract:
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Many studies have demonstrated a connection between the fibrillin matrix and TGFβ signalling, but at present the mechanistic basis for this link is unclear. An interaction between the C-terminus of Latent TGFβ Binding Protein 1 (LTBP1) and the N-terminus of fibrillin1 has previously been identified, and may have the potential to directly link the fibrillin matrix to TGFβ signalling.
To investigate the structural basis for this interaction, several multi-domain fragments of fibrillin...
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- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
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uuid:e154e0a2-c0cb-42bd-8b90-7a13460700c0
- Local pid:
- ora:9371
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Ian B Robertson
- Copyright date:
- 2012
Thesis
An investigation into the molecular mechanism of the fibrillin1 - LTBP1 interaction
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