Immunological responses to emerging phleboviruses

Thesis

Emerging viruses of the Phenuiviridae family threaten human and animal health across the globe. The mosquito-borne phlebovirus, Rift Valley fever virus (RVFV) is widespread across the African continent wherein regular deadly outbreaks amongst livestock constitute a significant economic burden. In 2009, a tick-borne banyangvirus, severe fever with thrombocytopaenia syndrome virus (SFTSV), emerged in China. Since emergence, SFTSV has spread rapidly and become a serious public health...

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Authors: Allen, E

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: virus neutralisation; phlebovirus; X-ray crystallography; structure-based vaccine design; structural virology; vaccination
• Subjects: Molecular virology; structural biology