Investigating the endogenous role of human n-acetyltransferase 1, as potential breast cancer biomarker, using chemical biology

Thesis

Human N-acetyltransferase 1 (hNAT1) is one of the ten most highly overexpressed genes in oestrogen-receptor-positive (ER+ve) breast cancers and its overexpression is strongly related to tumour grade. N-acetyltransferases from prokaryotic and eukaryotic kingdoms catalyse the transfer of an acetyl group from acetyl coenzyme A (CoA) to a variety of arylamines and arylhydrazines. While the other human isoenzyme hNAT2 has widely been assessed as a phase-II xenobiotic metabolising enzyme, ...

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Authors: Laurieri, N

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: naphthoquinone inhibitors; colourimetric biosensors; human arylamine N-acetyltransferase 1; breast cancer
• Subjects: Pharmacology; Medical sciences