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Thesis

Structure and dynamics of picornavirus capsids to inform vaccine design

Abstract:

The physical properties of viral capsids are major determinants of vaccine efficacy for several picornaviruses which impact on human and animal health. Current picornavirus vaccines are frequently produced from inactivated virus. Inactivation often reduces the stability of the virus capsid, causing a problem for Foot and Mouth Disease Virus (FMDV) where certain serotypes fall apart into pentameric assemblies below pH 6.5 or at temperatures slightly above 37°C, destroying their effectivenes...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Prof. David Stuart
Oxford college:
St Catherine's College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Funding agency for:
Kotecha, A
Grant:
WT086832MA
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:df739a5f-fdb2-4930-909f-d94ce274ce33
Local pid:
ora:8191
Deposit date:
2014-03-12

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