Thesis
Structure and dynamics of picornavirus capsids to inform vaccine design
- Abstract:
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The physical properties of viral capsids are major determinants of vaccine efficacy for several picornaviruses which impact on human and animal health. Current picornavirus vaccines are frequently produced from inactivated virus. Inactivation often reduces the stability of the virus capsid, causing a problem for Foot and Mouth Disease Virus (FMDV) where certain serotypes fall apart into pentameric assemblies below pH 6.5 or at temperatures slightly above 37°C, destroying their effectivenes...
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Funding
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:df739a5f-fdb2-4930-909f-d94ce274ce33
- Local pid:
- ora:8191
- Deposit date:
- 2014-03-12
Terms of use
- Copyright holder:
- Kotecha, A
- Copyright date:
- 2013
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