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Thesis

Genome mapping of malaria resistance genes: the host ligands of PfEMP1

Abstract:

Erythrocytes infected by mature forms of the Plasmodium falciparum parasite adhere to other components of the vascular space, a behavior considered critical to the pathogenesis of severe malaria. Adhesion is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP1), a highly variant antigen expressed by the parasite and subject to switching during the course of an infection. The host ligands of PfEMP1 include CD36, ICAM-1 and the ABO antigens. By employing a seri...

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Institution:
University of Oxford
Research group:
International Child Health
Oxford college:
Balliol College
Department:
Medical Sciences Division - Paediatrics,Department of

Contributors

Role:
Supervisor
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Funding agency for:
Andrew E. Fry
Publication date:
2009-07-09
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:df1ffe4b-ba67-4fc6-9024-b278b887d4f9
Local pid:
ora:3269

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