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Thesis

Investigations of the role of d-amino acid oxidase and serine racemase in schizophrenia

Abstract:

D-serine metabolism is implicated in schizophrenia pathophysiology. This is based on reduced D-serine levels in the disorder, its ameliorative effects therapeutically and the potential genetic contributions of its metabolic enzymes, D-amino acid oxidase (DAO) and serine racemase (SRR). D-serine is a gliotransmitter and the N-methyl D-aspartate receptor (NMDAR) co-agonist. Thus, altered D-serine metabolism may contribute to NMDAR hypofunction in schizophrenia. The research in this thesis wa...

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Institution:
University of Oxford
Research group:
Molecular Neuropathology Group
Oxford college:
Corpus Christi College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Louise Verrall
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:de3d94cc-8734-4c47-b453-fd4b12729441
Local pid:
ora:10130

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