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Thesis

Molecular mechanisms of recombination hotspots in humans

Abstract:

Meiotic recombination involves the exchange of DNA between two homologous chromosomes, forming cross-overs and gene conversion events. The cross-over process is important for the proper segregation of chromosomes during meiosis, and drives genetic diversity. Human hotspots are enriched for a 13-bp motif, CCNCCNTNNCCNC; a close match to this motif occurs in about 40% of our cross-over hotspots. A DNA binding protein called PRDM9, having histone trimethyltransferase (H3K4me3) activity, binds...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Division:
MSD
Department:
NDM
Role:
Supervisor
Division:
MSD
Department:
NDM
Role:
Supervisor

Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:dd26a44a-e190-42e3-b90f-d00269f8a7b4
Local pid:
ora:7510
Deposit date:
2013-10-24

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