Thesis icon

Thesis

Molecular mechanisms of recombination hotspots in humans

Abstract:

Meiotic recombination involves the exchange of DNA between two homologous chromosomes, forming cross-overs and gene conversion events. The cross-over process is important for the proper segregation of chromosomes during meiosis, and drives genetic diversity. Human hotspots are enriched for a 13-bp motif, CCNCCNTNNCCNC; a close match to this motif occurs in about 40% of our cross-over hotspots. A DNA binding protein called PRDM9, having histone trimethyltransferase (H3K4me3) activity, binds...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:dd26a44a-e190-42e3-b90f-d00269f8a7b4
Local pid:
ora:7510

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP