Thesis
Uncovering epithelial lineage complexity and cell fate trajectories in human intestinal organoids through advanced single-cell genomics
- Abstract:
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The human intestinal epithelium is a rapidly renewing, functionally diverse tissue responsible for nutrient absorption, barrier defence, and immunological regulation. Its complexity — marked by continuous turnover and the presence of rare, specialised lineages — presents substantial challenges for experimental modelling. While human intestinal epithelial organoids (hIEOs) have emerged as physiologically relevant ex vivo systems, limitations persist in reliably inducing full lineage complexity...
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- Files:
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(Preview, Dissemination version, pdf, 15.6MB, Terms of use)
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Authors
Contributors
+ Antanaviciute, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Contributor
+ Siejka-Zielińska, P
- Role:
- Contributor
+ Christoforidou, Z
- Role:
- Contributor
+ Babu, R
- Role:
- Contributor
+ Simmons, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
- ORCID:
- 0000-0003-3454-0710
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Pubs id:
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2416129
- Local pid:
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pubs:2416129
- Deposit date:
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2026-04-03
- ARK identifier:
Terms of use
- Copyright holder:
- Ana Sousa Gerós
- Copyright date:
- 2025
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