Thesis
Developing new methods to characterise circulating plasma biomarkers in abdominal aortic aneurysm
- Abstract:
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Abdominal aortic aneurysms (AAAs) are progressive dilations of the abdominal aorta that carry a high risk of rupture and mortality if untreated. Current management relies on imaging-based surveillance and surgical repair at diameter thresholds; however, marked inter-individual variability in growth underscores the lack of personalised prediction tools. This thesis develops and refines a mass spectrometry-based pipeline for the absolute quantification of circulating proteins and metabolic prof...
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- Files:
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(Preview, Dissemination version, pdf, 10.6MB, Terms of use)
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Authors
Contributors
+ Lee, R
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Surgical Sciences
- Research group:
- Oxford Abdominal Aortic Aneurysm (OxAAA) Study
- Role:
- Supervisor
- ORCID:
- 0000-0001-8621-5165
+ Fischer, R
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Target Discovery Institute
- Research group:
- Clinical Proteomics Group (CPG)
- Role:
- Supervisor
- ORCID:
- 0000-0002-9715-5951
+ Handa, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Surgical Sciences
- Research group:
- Oxford Abdominal Aortic Aneurysm (OxAAA) Study
- Oxford college:
- St Catherine's College
- Role:
- Supervisor
- ORCID:
- 0000-0001-7888-7180
+ Kessler, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Target Discovery Institute
- Role:
- Examiner
- ORCID:
- 0000-0002-8160-2446
+ Bown, M
- Institution:
- University of Leicester
- Role:
- Examiner
- ORCID:
- 0000-0002-6180-3611
+ Clarendon Fund, University of Oxford
More from this funder
- Grant:
- Ref. SFF2122_CB_MSD_1421777
- Programme:
- Clarendon Fund, University of Oxford
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2026-07-29
- ARK identifier:
Terms of use
- Copyright holder:
- Pierfrancesco Lapolla Losasso
- Copyright date:
- 2026
- Rights statement:
- © 2026 Pierfrancesco Lapolla Losasso. All rights reserved. Use of this thesis is subject to the Oxford University Research Archive Terms of Use.
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