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Modulating the heat-shock response : a potential therapy for lysosomal storage disorders

Abstract:

Lysosomal storage disorders (LSDs) comprise a broad disease group of inherited metabolic disorders, the majority of which are associated with CNS pathology, significant disability and reductions in life expectancy. LSDs are caused by mutations in genes encoding proteins critical for the correct functioning of lysosomal homeostasis. The disruption of lysosomal homeostasis results in the abnormal accumulation of lysosomal content, initiating intracellular pathological events, including calci...

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James Gray More by this author
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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