- Abstract:
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A repeated or prolonged stimulation with LPS induces in macrophage-lineage cells a refractory state known as endotoxin tolerance (ET). ET curtails inflammation and prevents tissue damage caused by sustained immune activation in sepsis. TNFα is required for ET induction and it is hypothesized that TNFα exerts its immuno-modulatory action via ET-associated molecules. In models of TNFα-driven disease, ET-associated molecules were investigated to determine their role in the progression from ...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Role:
- Supervisor
- Role:
- Supervisor
- Role:
- Supervisor
- Grant:
- BB/J013137/1
- Funding agency for:
- Project
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2018
Thesis
The role of IRAK3 in regulating immune-mediated inflammatory arthritis
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Authors
Contributors
+ Richard O. Williams
+ Felix I.L. Clanchy
+ John Silva
Funding
+ Biotechnology & Biological Sciences Research Council
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