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Thesis

The role of IRAK3 in regulating immune-mediated inflammatory arthritis

Abstract:

A repeated or prolonged stimulation with LPS induces in macrophage-lineage cells a refractory state known as endotoxin tolerance (ET). ET curtails inflammation and prevents tissue damage caused by sustained immune activation in sepsis. TNFα is required for ET induction and it is hypothesized that TNFα exerts its immuno-modulatory action via ET-associated molecules. In models of TNFα-driven disease, ET-associated molecules were investigated to determine their role in the progression from ...

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Department:
Federica Borghese
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Supervisor
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Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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