Thesis
The role of IRAK3 in regulating immune-mediated inflammatory arthritis
- Abstract:
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A repeated or prolonged stimulation with LPS induces in macrophage-lineage cells a refractory state known as endotoxin tolerance (ET). ET curtails inflammation and prevents tissue damage caused by sustained immune activation in sepsis. TNFα is required for ET induction and it is hypothesized that TNFα exerts its immuno-modulatory action via ET-associated molecules. In models of TNFα-driven disease, ET-associated molecules were investigated to determine their role in the progression from ...
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Authors
Contributors
+ Williams, R
Role:
Supervisor
+ Clanchy, F
Role:
Supervisor
+ Silva, J
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:d8bc6ae5-1114-4e40-affd-10f290fa9957
- Deposit date:
- 2018-09-04
Terms of use
- Copyright holder:
- Borghese, F
- Copyright date:
- 2018
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