Thesis icon

Thesis

The optimisation of an iPSC-derived cortical neuronal platform for the study of excitatory synaptic transmission and plasticity in neurological disorders

Abstract:

Many neurological disorders affecting the central nervous system exhibit alterations in glutamatergic synapse function. One such disorder is Alzheimer’s disease (AD), which affects 5 % of the world’s population. With an aging population and a lack of disease-modifying therapeutics, the prevalence of this disease is only expected to increase. Therefore, it is essential that we gain a greater understanding of AD pathogenesis in order to develop successful therapeutics. In AD, synapse loss is...

Expand abstract

Actions


Authors


Emma S Whiteley More by this author

Contributors

Department:
Department of Pharmacology, University of Oxford
Role:
Supervisor
Department:
Department of Physiology, Anatomy and Genetics, University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP