Thesis
The optimisation of an iPSC-derived cortical neuronal platform for the study of excitatory synaptic transmission and plasticity in neurological disorders
- Abstract:
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Many neurological disorders affecting the central nervous system exhibit alterations in glutamatergic synapse function. One such disorder is Alzheimer’s disease (AD), which affects 5 % of the world’s population. With an aging population and a lack of disease-modifying therapeutics, the prevalence of this disease is only expected to increase. Therefore, it is essential that we gain a greater understanding of AD pathogenesis in order to develop successful therapeutics. In AD, synapse loss is...
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- Files:
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(Preview, Dissemination version, pdf, 11.0MB, Terms of use)
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Authors
Contributors
+ Akerman, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
+ Wade-Martins, R
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy & Genetics
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:d6f6ac06-a370-4bd6-9a12-4c0205de2f4d
- Deposit date:
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2019-06-23
- ARK identifier:
Terms of use
- Copyright holder:
- Whiteley, ES
- Copyright date:
- 2018
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