Thesis
Cryocrystallographic and mechanistic studies on glycogen phosphorylase
- Abstract:
-
Glycogen phosphorylase (GPb) regulates the degradation of glycogen to glucose-1-phosphate and catalyses the first step of the reaction. Many studies have provided insights into the essentials of the catalytic mechanism. Previous time resolved crystallographic work using heptenitol has revealed a putative phosphate binding site at the active site of phosphorylase.
Using nojirimycin tetrazole, a transition state analogue, complexed with phosphate and both T and R state GPb crystals, t...
Expand abstract
Actions
Access Document
- Files:
-
-
(Preview, pdf, 26.3MB, Terms of use)
-
Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
-
uuid:d562f4f6-0a93-43a6-ad74-d480697d1b8c
- Local pid:
-
polonsky:5:2
- Source identifiers:
-
603832168
- Deposit date:
-
2017-10-05
- ARK identifier:
Terms of use
- Copyright holder:
- Mitchell, E; Mitchell, Edward Peter
- Copyright date:
- 1994
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
If you are the owner of this record, you can report an update to it here: Report update to this record