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Cryocrystallographic and mechanistic studies on glycogen phosphorylase

Abstract:

Glycogen phosphorylase (GPb) regulates the degradation of glycogen to glucose-1-phosphate and catalyses the first step of the reaction. Many studies have provided insights into the essentials of the catalytic mechanism. Previous time resolved crystallographic work using heptenitol has revealed a putative phosphate binding site at the active site of phosphorylase.

Using nojirimycin tetrazole, a transition state analogue, complexed with phosphate and both T and R state GPb crystals, t...

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Peer review status:
Peer Reviewed

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Department:
University of Oxford
This thesis was digitised thanks to the generosity of Dr Leonard Polonsky More from this funder
Publication date:
1994
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Local pid:
polonsky:5:2

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