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Thesis

18F-labelling of new chemotypes for drug discovery

Abstract:

In this thesis, the 18F-labelling of new "chemotypes" will be described with the aim of application in pharmaceutically interesting targets. In Chapter 1, a general introduction to the effect of fluorine substituents on molecular properties and reactivity is provided. This includes the application of organofluorine in both medicinal chemistry and positron emission tomography. Chapter 2 describes a novel silver-mediated 18F-labelling of Ar-SCF3, Ar OCF3 a...

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Tanatorn Khotavivattana More by this author

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Role:
Supervisor
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Funding agency for:
Tanatorn Khotavivattana
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Funding agency for:
Tanatorn Khotavivattana
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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