Assessing the impact of immunosuppressive drugs on regulatory T cell therapy

Thesis

Immunosuppressive drugs have facilitated the progression of solid organ transplantation from experimental therapy to routine practice, however transplant recipients are still susceptible to chronic rejection and co-morbidities. The emergence of regulatory T cells (Treg) as a key regulator of the immune system, together with an abundance of evidence from experimental transplant models, has led to clinical trials asking whether Treg can improve transplant outcomes. However, given that Treg c...

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Authors: Whatcott, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford