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Targeting the hypoxic tumour phenotype with T-cell immunotherapy

Abstract:

The hypoxic tumour phenotype is a widespread phenomenon in cancers that correlates with malignant behaviour and poor clinical outcomes. The induced expression of hypoxia-regulated genes through post-translational stabilization of hypoxia-inducible factor (HIF), represent a novel class of over expressed tumour antigens that may bear relevance for specific T cell immunity. To assess whether hypoxia inducible proteins can elicit specific T cell responses in vivo, experiments were carried out ...

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Institution:
University of Oxford
Department:
Medical Sciences Division

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Publication date:
2004
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603828400
URN:
uuid:d22f1d74-44eb-4560-9249-f6127accd1b1
Local pid:
td:603828400

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