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Thesis

T-cell interactions with second generation glass-supported lipid bilayers

Abstract:

T cells must efficiently scan and discriminate foreign antigen from self. Failure to do so leads to immunodeficiency or autoimmunity. How this process is achieved remains unclear, but recent developments have indicated the topology of the T-cell membrane, and nature of the contact interfaces formed with antigen presenting cells (APCs) may be key. Due to the difficulty of studying cellular contacts, in vitro systems that isolate and test specific elements of T cell-APC interface have been e...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0002-3698-5599
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Name:
Medical Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000265
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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