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Thesis

Molecular pathways leading to sleep and wakefulness in Drosophila

Abstract:

Sleep is a universal and highly conserved phenomenon across species; yet its operational mechanisms remain one of the greatest biological mysteries. In Drosophila, sleep homeostasis is largely mediated by the activity of neurons projecting to the dorsal fan-shaped body (dFB). Dopamine promotes wakefulness by inhibiting the activity of dFB neurons, switching them to a silent state. This wake-promoting effect is hypothesised to require the exocytosis of the potassium “leak” channel, Sandman,...

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Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Role:
Supervisor
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Name:
University of Oxford
Funding agency for:
Christodoulou, K
Grant:
B81205
Programme:
Gotch Memorial Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-03-14

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