Thesis
Sjögren’s disease autoantigen TRIM21/Ro52 is exposed during lytic cell death, facilitates immune complex formation and activates macrophages
- Abstract:
-
Sjögren’s disease (SjD) causes localised inflammation of the lacrimal and salivary glands (SGs), and autoantibody production against ubiquitously expressed intracellular proteins such as TRIM21/Ro52 and TROVE2/Ro60. TRIM21 has vital intracellular roles, as an Fc receptor and E3 ubiquitin ligase. It binds antibody Fc domains on opsonised pathogens, which have escaped extracellular immunity and entered cytosols. TRIM21 ubiquitinates these pathogenic targets, driving their proteasomal degrada...
Expand abstract
Actions
Authors
Contributors
+ Dustin, L
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Sub department:
- Kennedy Institute for Rheumatology
- Role:
- Supervisor
- ORCID:
- 0000-0002-2619-1867
+ Buckley, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Sub department:
- Kennedy Institute for Rheumatology
- Role:
- Supervisor
- ORCID:
- 0000-0001-6924-6402
+ Bezbradica Mirkovic, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDORMS
- Sub department:
- Kennedy Institute for Rheumatology
- Role:
- Supervisor
- ORCID:
- 0000-0003-1441-1727
+ University of Oxford
More from this funder
- Funder identifier:
- https://ror.org/052gg0110
- Grant:
- KENN 19 20 01
- Programme:
- Kennedy Trust Studentship, Kennedy Institute of Rheumatology, University of Oxford
+ University of Oxford
More from this funder
- Funder identifier:
- https://ror.org/052gg0110
- Programme:
- Henni Mester Studentship, University College Oxford
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
-
2268925
- Local pid:
-
pubs:2268925
- Deposit date:
-
2025-07-24
- ARK identifier:
Terms of use
- Copyright holder:
- Esther Lois Jones
- Copyright date:
- 2025
If you are the owner of this record, you can report an update to it here: Report update to this record