Elucidating novel roles for post-transcriptional regulation of gene expression in neural stem cell biology

Thesis

The brain develops from a relatively small number of neural stem cells whose highly regulated divisions lead to a large and diverse population of neurons. The major focus of the field has been on transcriptional regulation of protein expression, to direct this important process. The precise expression of different transcription factors and regulators determines the behaviour of the stem cell throughout development. In parallel to transcriptional regulation, RNA-binding proteins regulate th...

Expand abstract

Authors: Samuels, T

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: RNA biology; Drosophila; mRNA stability; RNA binding protein; Myc; Neural stem cell; Imp
• Subjects: RNA biology; Neurodevelopment; Molecular biology