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The role of adenosine A2A receptor signalling in cardiac fibrosis

Abstract:

Myocardial fibrosis contributes to the pathogenesis of diverse forms of cardiac hypertrophy. Recent evidence suggests a crucial role for purinergic signalling in the formation of tissue fibrosis. In particular, inhibition of adenosine A2A receptors (A2AR) in animal models for hepatic and skin fibrosis resulted in a reduction of fibrosis formation. The specific hypothesis of this investigation was that myocardial stress results in increased interstitial levels of adenosine, which activate c...

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Institution:
University of Oxford
Oxford college:
Pembroke College
Role:
Author
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Role:
Supervisor, Author
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Role:
Supervisor, Author
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:cfacf0d7-33c2-455f-97fe-4d5d6255a0a2
Deposit date:
2015-11-09

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