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Thesis

Regulation and heterogeneity of human mucosal-associated invariant T (MAIT) cells in blood and liver

Abstract:

Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like, effector memory T cells, that secrete proinflammatory cytokines and exhibit direct cytotoxic activity. Given their semi-invariant T cell receptor (TCR) and characteristic phenotype, MAIT cells appear as a homogeneous population. However, recent studies report some heterogeneity in surface marker expression, response to stimulation and cytokine production, as well as tissue-specific functionality. Whet...

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Division:
MSD
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0003-4307-9161
Role:
Supervisor
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Programme:
Wellcome Trust Infection, Immunology and Translational Medicine PhD Studentship
Grant:
109028/Z/15/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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