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Thesis

Statistical mechanics of nucleic acids under mechanical stress

Abstract:

In this thesis, the response of DNA and RNA to linear and torsional mechanical stress is studied using coarse-grained models. Inspired by single-molecule assays developed over the last two decades, the end-to-end extension, buckling and torque response behaviour of the stressed molecules is probed under conditions similar to experimentally used setups. Direct comparison with experimental data yields excellent agreement for many conditions. Results from coarse-grained simulations are also c...

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Institution:
University of Oxford
Research group:
Prof Ard A Louis / Prof Jonathan P K Doye
Oxford college:
Merton College
Department:
Mathematical,Physical & Life Sciences Division - Physics - Theoretical Physics

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:ce44cf50-2001-4f54-8e57-d1757f709fd6
Local pid:
ora:11450

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