Thesis
Statistical mechanics of nucleic acids under mechanical stress
- Abstract:
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In this thesis, the response of DNA and RNA to linear and torsional mechanical stress is studied using coarse-grained models. Inspired by single-molecule assays developed over the last two decades, the end-to-end extension, buckling and torque response behaviour of the stressed molecules is probed under conditions similar to experimentally used setups. Direct comparison with experimental data yields excellent agreement for many conditions. Results from coarse-grained simulations are also c...
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Authors
Contributors
+ Louis, A
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Supervisor
Funding
+ German Academic Exchange Service, Studienstiftung des deutsch Volkes
More from this funder
Funding agency for:
Matek, C
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:ce44cf50-2001-4f54-8e57-d1757f709fd6
- Local pid:
- ora:11450
- Deposit date:
- 2015-05-14
Terms of use
- Copyright holder:
- Matek, C
- Copyright date:
- 2014
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