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Thesis

Improving oral drug delivery: computational studies of proton dependent oligopeptide transporters

Alternative title:
Computational studies of peptide transporters
Abstract:

Proton dependent oligopeptide transporters (POTs) play a central role in nitrogen homeostasis by coupling the uptake of dipeptides and tripeptides to the proton electrochemical gradient across the plasma membrane. In human, members of this transporter family, PepT1 and PepT2, are critical modulators of drug pharmacokinetics as they facilitate the uptake and retention of numerous orally administered drugs including the β-lactam antibiotics. Rationally designing drugs to target these transpo...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
More from this funder
Name:
Wellcome Trust
Grant:
092970/788Z/10/Z
More from this funder
Name:
Terengganu Foundation (Malaysian Government)
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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