Thesis
Spatial profiling of the immune microenvironment by multiplex imaging identifies barriers to immunotherapy in colorectal liver metastases
- Abstract:
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Colorectal liver metastasis (CRLM) is the most frequent site of distant metastasis in colorectal cancer (CRC), affecting around 50% of CRC patients. Only 10–30% of CRLM patients were eligible for curative resection, with a low 5-year survival rate (35–55%) and a high recurrence rate (70%). Notably, most CRLMs are resistant to immune checkpoint blockade, prompting a need to map how immune failure is organised in space. In this study, we profiled the CRLM tumour microenvironment across tumour c...
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- Files:
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(Preview, Dissemination version, pdf, 15.0MB, Terms of use)
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Authors
Contributors
+ Gordon-Weeks, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Surgical Sciences
- Role:
- Supervisor
+ Fisher, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Role:
- Examiner
+ Frampton, A
- Role:
- Examiner
- DOI:
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2026-04-24
- ARK identifier:
Terms of use
- Copyright holder:
- Ranchu Cheng
- Copyright date:
- 2025
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