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Thesis

NMR studies on 2-oxoglutarate oxygenases

Abstract:

The work described in this Thesis has focused on the application of nuclear magnetic resonance (NMR) spectroscopy to study the Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases, a family of structurally related enzymes that are ubiquitous in plants, micro-organisms and animals. The work included enzyme mechanistic studies, NMR method development, protein NMR and method development for inhibitor discovery.

NMR was applied to study human γ-butyrobetaine hydroxylase (BBOX), an enzym...

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Institution:
University of Oxford
Research group:
Christopher J. Schofield and Timothy D. W. Claridge
Oxford college:
St Peter's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral

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