Hypoxia-activated delivery of chemical probes and imaging agents

Thesis

Regions of hypoxia are a common feature of solid tumours and are associated with an aggressive phenotype and resistance to chemotherapy and radiotherapy. The differences in redox environment between normoxic and hypoxic tissue can be exploited by hypoxia-activated prodrugs (HAPs), which enable targeted delivery of drugs and imaging agents. Several HAPs have been developed but have had limited success in the clinic, partly resulting from a lack of understanding of their distribution and act...

Expand abstract

Authors: Evans, C

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Positron Emission Tomography; Fluorescence Imaging; One-Electron Reduction; Hypoxia; Chemical Synthesis; Fluorescence Microscopy; Nitroreductase
• Subjects: Hypoxia; Oncology; Cancer Imaging; Chemical Biology; Chemistry, Organic