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Thesis

Hypoxia-activated delivery of chemical probes and imaging agents

Abstract:

Regions of hypoxia are a common feature of solid tumours and are associated with an aggressive phenotype and resistance to chemotherapy and radiotherapy. The differences in redox environment between normoxic and hypoxic tissue can be exploited by hypoxia-activated prodrugs (HAPs), which enable targeted delivery of drugs and imaging agents. Several HAPs have been developed but have had limited success in the clinic, partly resulting from a lack of understanding of their distribution and act...

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Department:
Department of Chemistry

Contributors

Department:
Department of Chemistry
Role:
Supervisor
Department:
Department of Oncology
Role:
Supervisor
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Grant:
NS/A000024/1
Funding agency for:
Project
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Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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