Thesis
Probing protein structure and dynamics through native MS and H/D exchange
- Abstract:
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This thesis details the development and application of mass spectrometry (MS) labelling strategies for use in structural biology, and, specifically, how they offer insight into the quaternary structure and dynamics of protein complexes.
Chapter 3 first demonstrates the utility of isotopic H/D exchange (HDX) strategies for probing the in solution dynamics and assembly of two protein systems. Firstly, I use solution HDX to probe the light-induced structural change of the FAD-bind...
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Funding
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Chandler, S
Grant:
BB/L017067/1
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Subjects:
- UUID:
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uuid:cced3b96-638a-4dbb-bd34-5b66d335cbc3
- Deposit date:
- 2019-09-16
Terms of use
- Copyright holder:
- Chandler, S
- Copyright date:
- 2019
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