Thesis
Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
- Abstract:
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Carnitine is an essential metabolite in the human body. It carries out several roles in human metabolism, including that in fatty acid metabolism. γ-Butyrobetaine hydroxylase (BBOX) is an Fe(II) and 2-oxoglutarate dependent oxygenase, which catalyses the final step of carnitine biosynthesis, i.e. hydroxylation of γ-butyrobetaine (GBB) to carnitine. Inhibition of BBOX has potential in the treatment for cardiovascular diseases.
The work described in this thesis focussed on mechanisti...
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Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:cccc1dd1-c063-4820-8ab1-58d698b04616
- Local pid:
- ora:9554
- Deposit date:
- 2014-12-10
Terms of use
- Copyright holder:
- Anna Rydzik
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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