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Thesis

Structure and mode of action of the TolA-TolB complex from Pseudomonas aeruginosa

Abstract:

Protein-protein interactions (PPIs) across the cell envelope of Gram-negative bacteria are critical for mediating signal transduction pathways that underpin cellular homeostasis. The Ton and Tol Pal systems are two conserved, ancestrally related protein networks that are also required for bacterial pathogenesis. Both Ton and Tol-Pal traverse the periplasm to effect different functions at the outer membrane (OM). Tol-Pal is composed of a homologous complex of three inner membrane protein...

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Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Examiner
Department:
University of Cambridge
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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