Thesis
Structure and mode of action of the TolA-TolB complex from Pseudomonas aeruginosa
- Abstract:
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Protein-protein interactions (PPIs) across the cell envelope of Gram-negative bacteria are critical for mediating signal transduction pathways that underpin cellular homeostasis. The Ton and Tol Pal systems are two conserved, ancestrally related protein networks that are also required for bacterial pathogenesis. Both Ton and Tol-Pal traverse the periplasm to effect different functions at the outer membrane (OM). Tol-Pal is composed of a homologous complex of three inner membrane protein...
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Authors
Contributors
+ Kleanthous, C
Department:
University of Oxford
Role:
Supervisor
+ Vakonakis, J
Department:
University of Oxford
Role:
Examiner
+ Clarke, J
Department:
University of Cambridge
Role:
Examiner
Funding
+ Natural Sciences and Engineering Research Council of Canada
More from this funder
Funding agency for:
Holmes, P
Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Keywords:
- Subjects:
- UUID:
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uuid:cccb0c88-5c89-4d21-81eb-70ebf513c7ab
- Deposit date:
- 2017-07-14
Terms of use
- Copyright holder:
- Holmes, P
- Copyright date:
- 2016
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