Journal article

Scaling-up of multi-capsule depth filtration systems by modelling flow and pressure distribution

Abstract:: Scaling-up of filtration systems in the pharmaceutical industry to provide the correct filtration capacity is a complex process. When several filters are used in parallel, the pressure and flow distribution within the system can be modelled using well-established constitutive laws to a high degree of accuracy, as shown in this paper. By combining the model with experimental fouling data, it is also possible to accurately predict the flow and pressure distribution during an entire filtration run. A process is discussed that uses this model to determine how the capacity of a filtration system can be accurately predicted using a minimal set of measurements.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Krupp, A., Please, C., Kumar, A., & Griffiths, I. (2016). Scaling-up of multi-capsule depth filtration systems by modelling flow and pressure distribution. Separation and Purification Technology, 172, 350–356.

MLA Style

Krupp, A, et al. “Scaling-up of Multi-Capsule Depth Filtration Systems by Modelling Flow and Pressure Distribution.” Separation and Purification Technology, vol. 172, 2016, pp. 350–56.

Chicago Style

Krupp, A, C Please, A Kumar, and I Griffiths. 2016. “Scaling-up of Multi-Capsule Depth Filtration Systems by Modelling Flow and Pressure Distribution.” Separation and Purification Technology 172: 350–56.
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Files:: Griffiths et al, Scaling-up of multi-capsule depth filtration ...

(Preview, Accepted manuscript, pdf, 347.5KB, Terms of use)

Publisher copy:: 10.1016/j.seppur.2016.07.028

Authors

+ Krupp, A More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Mathematical Institute
Role:: Author

+ Please, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Mathematical Institute
Role:: Author

+ Kumar, A More by this author

Role:: Author

+ Griffiths, I More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Mathematical Institute
Role:: Author

+ Royal Society More from this funder

Funding agency for:: Griffiths, I

+ Mathematical Institute, University of Oxford More from this funder

Funding agency for:: Krupp, A

+ Pall Corporation More from this funder

Funding agency for:: Krupp, A

Publisher:: Elsevier
Journal:: Separation and Purification Technology More from this journal
Volume:: 172
Pages:: 350-56
Publication date:: 2016-07-01
Acceptance date:: 2016-07-17
DOI:: 10.1016/j.seppur.2016.07.028
ISSN:: 1383-5866

Keywords:: Scale-up

Fouling

Depth filtration

Filter capacity

Modeling
Pubs id:: pubs:648600
UUID:: uuid:cc3a3020-2728-48df-ad6e-07ce6c27de91
Local pid:: pubs:648600
Source identifiers:: 648600
Deposit date:: 2016-10-10
ARK identifier:: ark:/29072/ora_cc3a3020272848dfad6e07ce6c27de91

Terms of use

Copyright holder:: Elsevier
Copyright date:: 2016
Notes:: © 2016 Published by Elsevier B.V.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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