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Clonal dynamics of TEL-AML1+ childhood ALL: an in vivo model

Abstract:

ETV6–RUNX1 gene fusion is an early or initiating genetic lesion of Childhood Acute Lymphoblastic Leukaemia, followed, in disease progression, by a modest number of recurrent or "driver" copy number alterations. Among patients diagnosed with this particular cytogenetic subtype of ALL cure rate reaches over 80% . However, treatment protocols are extremely demanding, and the molecular mechanisms driving drug-resistance and relapse in the remaining 10% of patient are sti...

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Department:
University of Oxford

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Awarding institution:
University of Oxford

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