Thesis
Clonal dynamics of TEL-AML1+ childhood ALL: an in vivo model
- Abstract:
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ETV6–RUNX1 gene fusion is an early or initiating genetic lesion of Childhood Acute Lymphoblastic Leukaemia, followed, in disease progression, by a modest number of recurrent or "driver" copy number alterations. Among patients diagnosed with this particular cytogenetic subtype of ALL cure rate reaches over 80% . However, treatment protocols are extremely demanding, and the molecular mechanisms driving drug-resistance and relapse in the remaining 10% of patient are still unknown. Recently a...
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Funding
Medical Research Council
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:cc29211b-b346-4596-b68d-312a6357d470
- Deposit date:
- 2015-10-19
Terms of use
- Copyright holder:
- Turati, V
- Copyright date:
- 2015
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