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Structure of the PfEMP1:EPCR complex and inhibition of the interaction

Abstract:

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family is central for Plasmodium falciparum infection. This family mediates interactions between the infected erythrocyte and the host endothelial surface, making it an obvious vaccine target. However this family is very diverse, with sixty different variants in the genome of each parasite. Despite the diversity within the PfEMP1 family, only around ten ligands have been identified. T...

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Department:
University of Oxford
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Author

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Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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