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Thesis

Functional genomics of the sepsis response

Abstract:

Sepsis is defined as a dysregulated immune response to infection causing organ dysfunction, and is a major area of unmet clinical need. Although conventionally considered a unified disease with a common pathway to organ failure and death, substantial clinical and molecular heterogeneity is seen, which has limited efforts to understand pathophysiology and improve therapeutic strategies. Sepsis is associated with global changes in gene expression, and genetic variants are known to affect th...

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Department:
Wellcome Centre for Human Genetics
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Department:
Wellcome Centre for Human Genetics
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Supervisor
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Funding agency for:
Katie Burnham
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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