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Thesis

Ultrasound-enhanced delivery of therapeutic agents to tumours using submicron cavitation nuclei

Abstract:

Cancer therapy is severely hampered by the poor delivery of agents out of the blood vessels and into tumours. This is due to the irregular vasculature, high interstitial pressure and dense extracellular matrix associated with tumour tissue. As a consequence, high doses of agents must be administered intravenously for effective accumulation in the tumour. This leads to a low therapeutic index, necessitates multiple administrations of the same drug, and for many cancer drugs, also leads to t...

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Division:
MPLS
Department:
Engineering Science
Department:
University of Oxford
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Name:
Engineering & Physical Sciences Research Council
Grant:
WT088877/Z/09/Z
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Name:
Research Councils UK
Grant:
EP/G036861/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:
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UUID:
uuid:cb82814d-cb45-40e4-b859-5b171895e817
Deposit date:
2016-03-18

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