Ultrasound-enhanced delivery of therapeutic agents to tumours using submicron cavitation nuclei

Thesis

Cancer therapy is severely hampered by the poor delivery of agents out of the blood vessels and into tumours. This is due to the irregular vasculature, high interstitial pressure and dense extracellular matrix associated with tumour tissue. As a consequence, high doses of agents must be administered intravenously for effective accumulation in the tumour. This leads to a low therapeutic index, necessitates multiple administrations of the same drug, and for many cancer drugs, also leads to t...

Expand abstract

Authors: Myers, R

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Keywords: Ultrasound; Cancer; Virology; Drug delivery; Nanotechnology; Cavitation
• Subjects: Drug targeting