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Thesis

Role of Notch ligands in tumour angiogenesis

Abstract:

The well conserved Notch signalling pathway plays a crucial role in vascular development and physiology. Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key notch ligands implicated in angiogenesis. Both ligands were shown to have opposite effects on vasculature. DLL4-Notch signalling inhibits sprouting resulting in fewer but better perfused blood vessels, promoting tumour growth. In contrast to DLL4, very little is known about JAG1- Notch signalling in tumour angiogenesis and its influence on...

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Institution:
University of Oxford
Research group:
Growth factor group
Oxford college:
Merton College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
More from this funder
Name:
Ministry of Higher Education Malaysia
Funding agency for:
Oon, C
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:cb237fdd-e532-406c-808b-8092257968c2
Local pid:
ora:5465
Deposit date:
2011-06-16

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